Expectations, scope, purpose and use

"What are you going to use this software for"?

This could be the first question to ask yourself.
For example, let's take the two most prominent and somehow opposite goals: will you be using the software mainly to publish papers or to manage a database? In the first case the Manuscript formatting function is likely to be the, or one of the most important features for you; in the latter case, searching and sorting will have more importance.